Delta-8-THC binds to the CB1 receptor like delta-9-THC, but its affinity for the receptor is different due to its slightly altered molecular structure. The CB1 receptor is responsible for mediating most of the psychotropic effects of THC

This differential binding may be responsible for the reported clearer high with reduced anxiety and more remarkable ability to concentrate often associated with delta-8-THC. 

Its unique molecular structure may also impact the chemical’s effects on other receptors and neural pathways.